Senescência das células-tronco mesenquimais para proposta terapêutica
DOI:
https://doi.org/10.29327/2335218.1.2-9Palavras-chave:
Células-tronco mesenquimais, tecido adiposo, senescência celular, terapêutica celularResumo
As CTM ganharam atenção significativa no campo da pesquisa por serem promissoras na terapêutica de diversas patologias, tanto na clínica humana quanto veterinária. Este cenário deve-se, principalmente, à plasticidade funcional dessas células como agente regenerativo e moduladoras do sistema imune, o que as tornam excelentes candidatas para a resolução da inflamação. A senescência celular caracteriza o envelhecimento da célula com diminuição de sua proliferação e atividades biológicas. A expansão in vitro das CTM pode acelerar esse processo e diminuir a sua capacidade de multiplicação e potencial de diferenciação em outros tipos celulares, tornando-as inviáveis para as propostas terapêuticas. Neste contexto, este artigo traz uma revisão narrativa sobre a importância da avaliação da senescência das CTM e sua influência nos diversos processos biológicos.
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